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High-Resolution Melting Assay (HRMA) is a Simple and Sensitive Stool-Based DNA Test for the Detection of Mutations in Colorectal Neoplasms
21 May 2012
Bing-Sheng Li, Xin-Ying Wang, An-Gao Xu, Feng-Li Ma, Qun-Ying Ma, Zao Li, Ji-Hong Liu, Ai-Hua Gan, Zhi-Jin Yu, Xiao-Hui Zhang, Bo Jiang
Abstract: Background: Stool-based DNA testing for colorectal cancer is becoming a favored alternative to existing DNA screening tests. However, current methods of analysis often become more complicate...
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Influence of KRAS p.G13D Mutation in Patients With Metastatic Colorectal Cancer Treated With Cetuximab
26 April 2012
Pablo Gajate, Javier Sastre, Inmaculada Bando, Teresa Alonso, Lourdes Cillero, Julian Sanz, Trinidad Caldés, Eduardo Díaz-Rubio
Micro-Abstract: Cetuximab is currently approved for the treatment of metastatic colorectal cancer with the KRAS wild-type gene. Some researchers suggest that p.G13D-mutated tumors could benefit from a...
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Outcomes in 144 Patients With Colorectal Cancer Treated in a Phase I Clinic: the MD Anderson Cancer Center Experience
26 April 2012
David S. Hong, Jesal C. Patel, Jennifer Wheler, Aung Naing, Ignacio Garrido-Laguna, Gerald Falchook, Siqing Fu, Apostolia M. Tsimberidou, Scott Kopetz, Sijin Win, Razelle Kurzrock
Micro-Abstract: We reviewed 144 consecutive patients with colorectal cancer enrolled in phase I studies and compared their progression-free survival (PFS) to that with their last line of standard chem...
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Oxaliplatin-Induced Hepatoportal Sclerosis, Portal Hypertension, and Variceal Bleeding Successfully Treated With Transjugular Intrahepatic Portosystemic Shunt
26 April 2012
Taoreed O. Lawal, Alton B. Farris, Bassel F. El-Rayes, Ram M. Subramanian, Hyun S. Kim
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A Novel Polypeptide Extracted from Ciona savignyi Induces Apoptosis Through a Mitochondrial-Mediated Pathway in Human Colorectal Carcinoma Cells
23 March 2012
Linyou Cheng, Chunguang Wang, Haizhou Liu, Fengxia Wang, Lanhong Zheng, Jin Zhao, Edward Chu, Xiukun Lin
Micro-Abstract: An ascidian is a marine animal that is important in the pharmacology field. Many compounds with special bioactivity, especially those with antitumor properties, have been developed fro...
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