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- Towards a pan-European consensus on the treatment of patients with colorectal liver metastases.Eur J Cancer. 2006; 42: 2212-2221
- Improved survival in metastatic colorectal cancer is associated with adoption of hepatic resection and improved chemotherapy.J Clin Oncol. 2009; 27: 3677-3683
- Chemotherapy and surgery: new perspectives on the treatment of unresectable liver metastases.Ann Oncol. 2003; 14: ii13-ii16
- Does chemotherapy prior to liver resection increase the potential for cure in patients with metastatic colorectal cancer? A report from the European Colorectal Metastases Treatment Group.Eur J Cancer. 2007; 43: 2037-2045
- A phase II experience with neoadjuvant irinotecan (CPT-11), 5-fluorouracil (5-FU) and leucovorin (LV) for colorectal liver metastases.BMC Cancer. 2009; 9: 156
- Importance of response to neoadjuvant chemotherapy in potentially curable colorectal cancer liver metastases.BMC Cancer. 2008; 8: 120
- Perioperative chemotherapy with FOLFOX4 and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC Intergroup trial 40983): a randomised controlled trial.Lancet. 2008; 371: 1007-1016
- Neoadjuvant treatment of unresectable colorectal liver metastases: correlation between tumour response and resection rates.Ann Oncol. 2005; 16: 1311-1319
- Colorectal cancer metastasis resectability after treatment with the combination of oxaliplatin, irinotecan and 5-fluorouracil. Final results of a phase II study.Acta Oncol. 2008; 47: 286-292
- Oxaliplatin, fluorouracil, and leucovorin for patients with unresectable liver-only metastases from colorectal cancer: a North Central Cancer Treatment Group phase II study.J Clin Oncol. 2005; 23: 9243-9249
- Final analysis of colorectal cancer patients treated with irinotecan and 5-fluorouracil plus folinic acid neoadjuvant chemotherapy for unresectable liver metastases.Br J Cancer. 2007; 97: 1035-1039
- Resection of nonresectable liver metastases from colorectal cancer after neoadjuvant chemotherapy.Ann Surg. 1996; 224 (discussion 520-2.): 509
- Phase III trial of infusional fluorouracil, leucovorin, oxaliplatin, and irinotecan (FOLFOXIRI) compared with infusional fluorouracil, leucovorin, and irinotecan (FOLFIRI) as first-line treatment for metastatic colorectal cancer: the Gruppo Oncologico Nord Ovest.J Clin Oncol. 2007; 25: 1670-1676
- Long-term survival of patients with unresectable colorectal cancer liver metastases following infusional chemotherapy with 5-fluorouracil, leucovorin, oxaliplatin and surgery.Ann Oncol. 1999; 10: 663-669
- Liver resection after irinotecan, 5-fluorouracil, and folinic acid for patients with unresectable colorectal liver metastases: a multicenter phase II study by the Cancer Therapeutic Research Group.Med Oncol. 2005; 22: 303-312
- Triplet combination of fluoropyrimidines, oxaliplatin, and irinotecan in the first-line treatment of metastatic colorectal cancer.Clin Colorectal Cancer. 2008; 7: 7-14
- Neoadjuvant treatment of unresectable liver disease with irinotecan and 5-fluorouracil plus folinic acid in colorectal cancer patients.Ann Oncol. 2004; 15: 933-939
- Oxaliplatin combined with irinotecan and 5-fluorouracil/leucovorin (OCFL) in metastatic colorectal cancer: a phase I-II study.Ann Oncol. 2005; 16: 762-766
- FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: a randomized GERCOR study.J Clin Oncol. 2004; 22: 229-237
- OPTIMOX1: a randomized study of FOLFOX4 or FOLFOX7 with oxaliplatin in a stop-and-Go fashion in advanced colorectal cancer–a GERCOR study.J Clin Oncol. 2006; 24: 394-400
- Impact of surgery on survival in palliative patients with metastatic colorectal cancer after first line treatment with weekly 24-hour infusion of high-dose 5-fluorouracil and folinic acid.Ann Oncol. 2001; 12: 1721-1727
- Tritherapy with fluorouracil/leucovorin, irinotecan and oxaliplatin (FOLFIRINOX): a phase II study in colorectal cancer patients with non-resectable liver metastases.Cancer Chemother Pharmacol. 2008; 62: 195-201
- Treatment with 5-fluorouracil/folinic acid, oxaliplatin, and irinotecan enables surgical resection of metastases in patients with initially unresectable metastatic colorectal cancer.Ann Surg Oncol. 2006; 13: 58-65
- Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer.J Clin Oncol. 2009; 27: 663-671
- Surgery with curative-intent in patients treated with first-line chemotherapy plus bevacizumab for metastatic colorectal cancer First BEAT and the randomised phase-III NO16966 trial.Br J Cancer. 2009; 101: 1033-1038
- Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer.N Engl J Med. 2009; 360: 1408-1417
- Induction of resectability of colorectal liver metastases (CLM) with cetuximab (Cmab) plus CPT-11/5-fluorouracil (5-FU)/leucovorin(FA)/oxaliplatin (L-OHP) (CPT-11-FFL) (POCHER trial).Eur J Cancer Supplements. 2009; 7 (P-6086).: 348
Masi G, Loupakis F, Baldi G, et al. First-line irinotecan, oxaliplatin and infusional 5-FU/LV(FOLFOXIRI) in combination with bevacizumab (BV). Presented at: the American Society of Clinical Oncology: 2008 Gastrointestinal Cancers Symposium; January 25-27, 2008; Orlando, FL. Abstract 363.
- Long-term outcome of initially unresectable metastatic colorectal cancer patients treated with 5-fluorouracil/leucovorin, oxaliplatin, and irinotecan (FOLFOXIRI) followed by radical surgery of metastases.Ann Surg. 2009; 249: 420-425
Ychou M, Desseigne F, Thezenas S, et al. Preliminary results of a multicentre phase II trial evaluating cetuximab in combination with FOLFIRINOX (LV5FU + Irinotecan + Oxaliplatin) as first line treatment of metastatic colorectal cancer (mCRC) patients. Presented at: the American Society of Clinical Oncology: 2009 Gastrointestinal Cancers Symposium; January 15-17, 2009; San Francisco, CA. Abstract 450.
- Cetuximab and irinotecan/5-fluorouracil/folinic acid is a safe combination for the first-line treatment of patients with epidermal growth factor receptor expressing metastatic colorectal carcinoma.Ann Oncol. 2006; 17: 450-456
- Tumour response and secondary resectability of colorectal liver metastases following neoadjuvant chemotherapy with cetuximab: the CELIM randomised phase 2 trial.Lancet Oncol. 2010; 11: 38-47
- Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer.N Engl J Med. 2004; 350: 2335-2342
- Preliminary results from a phase II study of infusional 5-FU, leucovorin and irinotecan (FOLFIRI) plus bevacizumab as first-line treatment for metastatic colorectal cancer (mCRC).J Clin Oncol. 2006; 24 (abstract 3579).: 165s
- Cetuximab in combination with irinotecan/5-fluorouracil/folinic acid (FOLFIRI) in the initial treatment of metastatic colorectal cancer: a multicentre two-part phase I/II study.BMC Cancer. 2009; 9: 112
- Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: a randomized phase III study.J Clin Oncol. 2008; 26: 2013-2019
- Phase II trial of cetuximab in combination with fluorouracil, leucovorin, and oxaliplatin in the first-line treatment of metastatic colorectal cancer.J Clin Oncol. 2007; 25: 5225-5232
Folprecht G, Gruenberger T, Hartmann JT, et al. Cetuximab plus FOLFOX6 or cetuximab plus FOLFIRI as neoadjuvant treatment of nonresectable colorectal liver metastases: A randomized multicenter study (CELIM-study). Presented at: the American Society of Clinical Oncology: 2009 Gastrointestinal Cancers Symposium; January 15-17, 2009; San Francisco, CA. Abstract 296.
- Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer.N Engl J Med. 2004; 350: 2343-2351
- Combined-modality treatment for resectable metastatic colorectal carcinoma to the liver: surgical resection of hepatic metastases in combination with continuous infusion of chemotherapy–an intergroup study.J Clin Oncol. 2002; 20: 1499-1505
- Multicenter randomized trial of adjuvant fluorouracil and folinic acid compared with surgery alone after resection of colorectal liver metastases: FFCD ACHBTH AURC 9002 trial.J Clin Oncol. 2006; 24: 4976-4982
- Adjuvant chemotherapy after potentially curative resection of metastases from colorectal cancer: A pooled analysis of two randomized trials.J Clin Oncol. 2008; 26: 4906-4911
- Hepatic arterial infusion of chemotherapy after resection of hepatic metastases from colorectal cancer.N Engl J Med. 1999; 341: 2039-2048
- Fluorouracil (FU) plus l-leucovorin (l-LV) versus observation after potentially curative resection of liver or lung metastases from colorectal cancer (CRC): results of the ENG (EORTC/NCIC CTG/GIVIO) randomized trial.Proc Am Soc Clin Oncol. 2002; 21 (abstract 592).: 149a
- A randomized phase III study comparing adjuvant 5-fluorouracil/folinic acid with FOLFIRI in patients following complete resection of liver metastases from colorectal cancer.Ann Oncol. 2009; 20: 1964-1970
Bathe OF, Ernst S, Sutherland F, et al. Neoadjuvant irinotecan (CPT-11), 5-fluorouracil (5-FU), and leucovorin (LV) for colorectal liver metastases: A means of selecting candidates for resection. Presented at: the American Society of Clinical Oncology: 2006 Gastrointestinal Cancers Symposium; January 26-28, 2006; San Francisco, CA. Abstract 194.
- Presurgical chemotherapy in patients being considered for liver resection.Oncologist. 2007; 12: 825-839
- Importance of response to neoadjuvant chemotherapy in patients undergoing resection of synchronous colorectal liver metastases.J Gastrointest Surg. 2003; 7 (discussion 116-7.): 109
- Neoadjuvant chemotherapy followed by hepatectomy for primarily resectable colorectal cancer liver metastases.Hepatogastroenterology. 2009; 56: 829-834
- Bevacizumab, capecitabine, and oxaliplatin as neoadjuvant therapy for patients with potentially curable metastatic colorectal cancer.J Clin Oncol. 2008; 26: 1830-1835
- Perioperative or adjuvant therapy for resectable colorectal hepatic metastasis.J Clin Oncol. 2008; 26: 4862-4863
- Is there a survival benefit to neoadjuvant versus adjuvant chemotherapy, combined with surgery for resectable colorectal liver metastases?.World J Surg. 2009; 33: 1028-1034
- Tumor progression while on chemotherapy: a contraindication to liver resection for multiple colorectal metastases?.Ann Surg. 2004; 240 (discussion 61-4.): 1052-1061
- Complete response of colorectal liver metastases after chemotherapy: does it mean cure?.J Clin Oncol. 2006; 24: 3939-3945
- Colorectal liver metastases contract centripetally with a response to chemotherapy: a histomorphologic study.Cancer. 2008; 112: 362-371
- Severe hepatic sinusoidal obstruction associated with oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer.Ann Oncol. 2004; 15: 460-466
- Perioperative complications in patients undergoing major liver resection with or without neoadjuvant chemotherapy.J Gastrointest Surg. 2003; 7: 1082-1088
- Chemotherapy regimen predicts steatohepatitis and an increase in 90-day mortality after surgery for hepatic colorectal metastases.J Clin Oncol. 2006; 24: 2065-2072
- Liver histology and surgical outcomes after preoperative chemotherapy with fluorouracil plus oxaliplatin in colorectal cancer liver metastases.J Clin Oncol. 2006; 24: 4983-4990
- Influence of preoperative chemotherapy on the risk of major hepatectomy for colorectal liver metastases.Ann Surg. 2006; 243: 1-7
- Sinusoidal injury increases morbidity after major hepatectomy in patients with colorectal liver metastases receiving preoperative chemotherapy.Ann Surg. 2008; 247: 118-124
Zorzi D, Kishi Y, Maru DM, et al. Effect of extended preoperative chemotherapy on pathologic response and postoperative liver insufficiency after hepatic resection for colorectal liver metastases. Presented at: the American Society of Clinical Oncology: 2009 Gastrointestinal Cancers Symposium; January 15-17, 2009; San Francisco, CA. Abstract 295.
- Outcome of initially unresectable metastatic colorectal cancer (MCRC) patients treated with first-line FOLFOXIRI followed by R0 surgical resection of metastases.J Clin Oncol. 2008; 26 (abstract 4074).: 196s
- Preoperative chemotherapy does not increase morbidity or mortality of hepatic resection for colorectal cancer metastases.Ann Surg Oncol. 2009; 16: 35-41
- Safe liver resection following chemotherapy for colorectal metastases is a matter of timing.Br J Cancer. 2007; 96: 1037-1042
- Risk factors for chemotherapy-associated liver injuries: A multivariate analysis of a group of 146 patients with colorectal metastases.Surgery. 2009; 145: 362-371
- Improving long-term outcomes for patients with liver metastases from colorectal cancer.J Clin Oncol. 2005; 23: 9063-9066
- VEGF: A key therapeutic target for the treatment of cancer-insights into its role and pharmacological inhibition.Targeted Oncology. 2007; 2: 153-164
Bevacizumab (Avastin) Summary of product characteristics: Roche Pharmaceuticals.
- Lack of evidence for increased operative morbidity after hepatectomy with perioperative use of bevacizumab: a matched case-control study.Ann Surg Oncol. 2007; 14: 759-765
- Efficacy and safety of bevacizumab with standard first-line fluoropyrimidine-based chemotherapy in patients with metastatic colorectal cancer: FIRST BEAT.Ann Oncol. 2008; 19 (abstract O-029).: vi17
- Preoperative bevacizumab does not significantly increase postoperative complication rates in patients undergoing hepatic surgery for colorectal cancer liver metastases.J Clin Oncol. 2008; 26: 5254-5260
- Combination of surgery and chemotherapy and the role of targeted agents in the treatment of patients with colorectal liver metastases: recommendations from an expert panel.Ann Oncol. 2009; 20: 985-992
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