Abstract
Background
Increased rates of long-term survival after CRC diagnosis are accompanied by increases
in the incidence of BMs. Here, we retrospectively evaluated the outcomes of patients
with BMs from CRC.
Materials and Methods
We reviewed the records of 1364 patients with CRC treated between January 1999 and
December 2010 at Kinki University Hospital in Japan. Twenty-five of these patients
developed BMs. Log-rank tests and Cox regression analyses were used to assess potential
prognostic factors for survival.
Results
Among the patients with BMs, BMs developed a median of 25.3 (range, 11.4-111) months
after primary CRC surgery. There was a median of 2 BMs per patient. Eleven patients
had solitary BMs. Concomitant extracerebral metastases, particularly lung metastases,
were found in 23 patients. Twenty-three patients were receiving systemic chemotherapy
at the time of diagnosis with BMs. After the development of BMs, the median survival
time (MST) was 2.8 months. The MST was 4.8 months among patients who underwent neurosurgical
resection (n = 6) or stereotactic surgery (n = 9, including combined therapy in 2 patients)
and 1.5 months among patients who underwent whole-brain radiotherapy only or best
supportive care (n = 12). In multivariate analysis, single BMs and additional systemic
chemotherapy after BMs diagnosis were significantly associated with overall survival
(P = .022 and .023, respectively).
Conclusion
Our results suggest that advancements in continuing systemic chemotherapy prolong
survival among patients with BMs from CRC. Clinicians should be especially aware of
BMs in patients with lung metastases.
Keywords
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Article info
Publication history
Published online: September 18, 2014
Accepted:
September 10,
2014
Received in revised form:
August 14,
2014
Received:
May 20,
2014
Identification
Copyright
© 2014 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
