Abstract
Background
Oxaliplatin is an effective drug used mainly for advanced colorectal cancer. Neurotoxicity
is the major side effect of oxaliplatin. The present clinical and neurophysiologic
study was conducted to evaluate patients receiving oxaliplatin therapy.
Patients and Methods
Thirty-one consecutive patients with colorectal cancer who received oxaliplatin therapy
were followed up for more than 3 years. The patients underwent clinical and neurophysiologic
tests for large and small fiber function at every visit.
Results
Most of the patients received oxaliplatin-based chemotherapy at the initial dose of
130 mg/m2 for 6 to 8 cycles, normally every 3 weeks. Acute neurotoxicity with cold and mechanical
hyperalgesia was reported by the vast majority of patients after each cycle of therapy
and was confirmed by the quantitative sensory, filament, and axon reflex test. Chronic
sensory cumulative neuropathy developed in most of the patients after the middle of
therapy with numbness and was assessed using clinical scales, nerve conduction studies,
and the vibration threshold. Our results support the persistence of the sensory nerve
deficits for years after cessation of oxaliplatin therapy.
Conclusion
Our study has confirmed the results of a few previous long-term studies concerning
the persistence of chronic large sensory fiber neuropathy and the influence of the
cumulative dose of oxaliplatin on the development and severity of the chronic neuropathy.
Our findings have improved the knowledge about the acute oxaliplatin-induced neurotoxicity
using the C-fiber axon reflex response.
Keywords
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Article info
Publication history
Published online: February 25, 2016
Accepted:
February 3,
2016
Received:
October 14,
2015
Identification
Copyright
© 2016 Elsevier Inc. All rights reserved.
