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Defibrotide for Sinusoidal Obstruction Syndrome and Nodular Regenerative Hyperplasia After Oxaliplatin-Based Hepatic Intra-Arterial Chemotherapy: A Case Report

Published:October 16, 2021DOI:https://doi.org/10.1016/j.clcc.2021.10.003

      Clinical Practice Points

      • Sinusoidal obstruction syndrome (SOS) is a life-threatening complication of oxaliplatin-based chemotherapy.
      • Nodular regenerative hyperplasia can be associated at a late stage of SOS, and should be suspected in case of signs of portal hypertension such as thrombocytopenia or splenomegaly.
      • To our knowledge, this is the first report of SOS occurring after oxaliplatin hepatic arterial infusion (HAI).
      • We report a case of a 43-year-old man, with colorectal liver metastases with SOS associated with nodular regenerative hyperplasia, diagnosed after 28 cycles of oxaliplatin-based HAI, treated with defibrotide but with a fatal outcome.

      Keywords

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