Clinical Practice Points
- •Sinusoidal obstruction syndrome (SOS) is a life-threatening complication of oxaliplatin-based chemotherapy.
- •Nodular regenerative hyperplasia can be associated at a late stage of SOS, and should be suspected in case of signs of portal hypertension such as thrombocytopenia or splenomegaly.
- •To our knowledge, this is the first report of SOS occurring after oxaliplatin hepatic arterial infusion (HAI).
- •We report a case of a 43-year-old man, with colorectal liver metastases with SOS associated with nodular regenerative hyperplasia, diagnosed after 28 cycles of oxaliplatin-based HAI, treated with defibrotide but with a fatal outcome.
Keywords
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Article info
Publication history
Published online: October 16, 2021
Accepted:
October 13,
2021
Received in revised form:
October 5,
2021
Received:
May 10,
2021
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Copyright
© 2021 Elsevier Inc. All rights reserved.
