Abstract
Background
Obesity is associated with an increased risk of development and recurrence of colorectal
cancer. The role of obesity in metastatic colorectal cancer patients (pts) is still
unclear, especially in those treated with triplet plus bevacizumab (bev). The aim
of our study was to evaluate the prognostic and predictive role of BMI in metastatic
colorectal cancer pts treated with FOLFOXIRI plus bev or FOLFIRI/FOLFOX plus bev in
the TRIBE and TRIBE-2 trial.
materials and Methods
A total of 1160 pts enrolled in TRIBE and TRIBE-2 trials were included. Baseline height
and weight were used to assign pts to one of the following BMI categories: underweight
(group A = BMI <18.5 kg/m2; 52 pts), normal (group B = BMI 18.5-29.9 kg/m2; 952 pts) and obese (group C > 30 kg/m2; 156 pts).
Results
In our population, no differences in terms of PFS (P = .43) or OS (P = .99) resulted between 3 groups. No interaction effect between treatment arm and
BMI was evident in terms of PFS (Group A HR: 0.65 [95%CI: 0.36-1.16]; Group B HR:
0.77 [95%CI: 0.67-0.88]; Group C HR: 0.67 [95%CI: 0.48-0.93]; P for interaction = .75) or OS (Group A HR: 0.57 [95%CI: 0.29-1.12]; Group B HR: 0.85
[95%CI: 0.73-0.99];Group C HR: 0.69 [95%CI: 0.48-1.01] P for interaction = .36). No statistically significant difference in terms of dose
reductions due to toxicities were found according to BMI in the overall population
(P = .48) and in pts treated with FOLFOXIRI plus bev (P = .57).
Conclusion
BMI was neither prognostic or predictive for PFS and OS in our population. Our analyses
showed that the advantage of FOLFOXIRI plus bev versus FOLFIRI/FOLFOX plus bev was
independent from BMI.
Keywords
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Article Info
Publication History
Published online: February 19, 2022
Accepted:
February 13,
2022
Received in revised form:
January 21,
2022
Received:
December 15,
2021
Identification
Copyright
© 2022 Published by Elsevier Inc.
