Abstracts
Background
Patients with T2N0 squamous cell carcinoma of the anal canal (SCCA) have comprised
less than 30% of patients enrolled in phase III clinical trials of curative-intent
definitive chemoradiation. We aimed to evaluate treatment outcomes of these patients
according to dose-intensity of chemoradiation.
Materials and Methods
Retrospective multicenter study of patients with T2N0 SCCA, with the primary endpoint
to compare the progression-free survival (PFS) of patients treated with full definitive
chemoradiotherapy (f-CRT, CRT with 2 drugs) versus a nonstandard treatment (NST; radiotherapy
only or CRT with 1 drug). Secondary outcomes were rates of complete response (CR),
salvage surgery, and colostomy. PFS time was analyzed using the Kaplan-Meier method
and differences in survival outcomes were assessed using the log-rank test and adjusted
for prognostic covariates using a multivariable Cox regression model
Results
From March 2006 to January 2020, 74 patients were included. Most patients (n = 58; 78.4%) received f-CRT. In a median follow up time of 66.1 months, the unadjusted
median PFS was 128.3 months (95% confidence interval [CI] 105.5-151.1) for f-CRT versus
74.1 months for NST (95% CI 45.8-102.4; P = .067). CR was achieved by 51 (87.9%) versus 11 (68.9%; P = .065) patients treated with f-CRT or an NST, respectively. Comparing f-CRT versus
NST, the colostomy rates were higher for those treated with an NST: 5 (32.8%) versus
5 (9.5%; P = .019)
Conclusion
For patients with T2N0 SCCA, f-CRT remains the standard treatment, offering higher
CR and less likelihood of colostomy.
Keywords
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Article Info
Publication History
Published online: June 06, 2022
Accepted:
March 11,
2022
Received in revised form:
March 8,
2022
Received:
January 5,
2022
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2022 Published by Elsevier Inc.
