Abstract
Colon cancer needs better screening and treatment options. Its incidence in the young
population is rising. Recent changes in guidelines recommend beginning screening for
colon cancer at the age of 45. Circulating tumor DNA presents an opportunity to select
patients for administration of adjuvant chemotherapy. Immunotherapy is an option for
patients with a deficiency in mismatch repair proteins. However, its efficacy outside
of this group of patients remains a challenge. Targeted therapies such as BRAF inhibitors
are an option for patients with poor prognosis, for whom cytotoxic chemotherapy is
not as effective. This review presents the recently published evidence regarding screening
and treating patients with colon cancer.
Keywords
Abbreviations:
CC (Colon cancer), NSAIDS (Non-steroidal anti-inflammatory drugs), ctDNA (Circulating tumor DNA), dMMR (Deficient mismatch repair), MSI (Microsatellite instability), FOLFOX (5-Fluorouracil Oxaliplatin), CAPEOX (Capecitabine Oxaliplatin), FOLFIRI (5-fluorouracil irinotecan)To read this article in full you will need to make a payment
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Article Info
Publication History
Published online: June 03, 2022
Accepted:
May 31,
2022
Received in revised form:
May 26,
2022
Received:
March 30,
2022
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2022 Elsevier Inc. All rights reserved.
