Clinical Practice Points
- •Peritoneal mesothelioma is much rarer than its pleural counterpart; hence, there is a paucity of data to guide management, which usually follows guidelines available for pleural mesothelioma, despite reported molecular differences between the 2 anatomic sites.
- •A recent randomized clinical trial demonstrated better response rate, progression-free survival and overall survival with dual immunotherapy (ipilimumab and nivolumab) than with cytotoxic chemotherapy in pleural mesothelioma.
- •The clinical and radiological response observed with dual immunotherapy in a patient with peritoneal mesothelioma suggests that this a promising therapeutic approach.
Keywords
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References
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- Mesothelioma incidence in 50 states and the District of Columbia, United States, 2003-2008.Int J Occup Environ Health. 2013; 19: 1-10
- First-line nivolumab plus ipilimumab in unresectable malignant pleural mesothelioma (CheckMate 743): a multicentre, randomised, open-label, phase 3 trial.Lancet. 2021; 397: 375-386
- Nivolumab activity in advanced refractory malignant peritoneal mesothelioma.Eur J Cancer. 2021; 144: 386-388
- Nivolumab for malignant peritoneal mesothelioma.BMJ Case Rep. 2020; 13: e237721https://doi.org/10.1136/bcr-2020-237721
- Guidelines for pathologic diagnosis of malignant mesothelioma 2017 update of the consensus statement from the International Mesothelioma Interest Group.Arch Pathol Lab Med. 2018; 142: 89-108
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Article Info
Publication History
Published online: August 30, 2022
Accepted:
August 2,
2022
Received in revised form:
July 27,
2022
Received:
June 26,
2022
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2022 Elsevier Inc. All rights reserved.
