Abstract
Patients with metastatic or advanced pancreatic neuroendocrine tumors (NETs) carry
poorer prognoses relative to patients with other NETs due to bulkier and often, more
proliferative baseline disease. Patients with these tumors also possess more approved
treatment options relative to patients with other NETs, making therapeutic sequencing
nuanced. As such, defining optimal therapeutic sequencing and developing more potent
cytoreductive treatments for patients are significant areas of research need in the
field. Herein this review, we discuss the current systemic therapy landscape, our
approach to therapeutic sequencing in the clinic and ongoing studies seeking to define
optimal sequencing of systemic therapies, and novel therapeutics in development, for
patients with pancreatic NETs. We limit the scope of this latter topic to agents with
preclinical or clinical rationale over the last 8 years to provide a contemporary
view of the drug development landscape and focus primarily on new types of peptide
receptor radionuclide therapy, anti-vascular endothelial growth factor receptor tyrosine
kinase inhibitors and anti-vascular endothelial growth receptor tyrosine kinase inhibitor
plus immunotherapy combinations.
Keywords
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Article Info
Publication History
Published online: August 28, 2022
Accepted:
August 2,
2022
Received in revised form:
July 21,
2022
Received:
April 19,
2022
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2022 Elsevier Inc. All rights reserved.
