Abstract
Introduction
To retrospectively evaluate the safety and efficacy of computed tomography (CT)-guided
iodine-125 (125I) seed implantation for patients with abdominal incision metastases from colorectal
cancer.
Materials and Methods
Data of patients with abdominal incision metastases of colorectal cancer from November
2010 to October 2020 were retrospectively reviewed. Each incisional metastasis was
percutaneously treated with 125I seed implantation under CT guidance. Follow-up contrast-enhanced CT was reviewed,
and the outcomes were evaluated in terms of objective response rate, complications,
and overall survival.
Results
A total of 17 patients were enrolled in this study. The median follow-up was 18 months
(range, 2.7-22.1 months). At 3, 6, 12, and 18 months after the treatment, objective
response rate was 52.9%, 63.6%, 33.3%, and 0%, respectively. A small amount of local
hematoma occurred in two patients and resolved spontaneously without any treatment.
Two patients experienced a minor displacement of radioactive seeds with no related
symptoms. Severe complications, such as massive bleeding and radiation injury, were
not observed. No ≥ grade 3 adverse events were identified. By the end of follow-up,
14 patients died of multiple hematogenous metastases. The one-year overall survival
rate was 41.6%, and the median overall survival was 8.6 months.
Conclusion
CT-guided 125I seed implantation brachytherapy is safe and feasible for patients with abdominal
incision metastases from colorectal cancer.
Keywords
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Article info
Publication history
Published online: November 03, 2022
Accepted:
October 30,
2022
Received:
July 12,
2022
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2022 Elsevier Inc. All rights reserved.
